Chemicals released after exercise can slow breast cancer

Exercise has long been linked to better outcomes for women with breast cancer – and a recent study might explain why.

According to researchers from Denmark, physical activity that’s intense enough to cause breathlessness creates a chemical release in the body.

This releases compounds called catecholamines and one in particular – epinephrine – helps suppress the growth of tumour cells.

Fighting fit: Physical activity that’s intense enough to cause breathlessness creates a chemical release in the body which slows tumour growth

THE RESEARCH 

Senior study author, Pernille Hojman, from University of Copenhagen, told Reuters Health: ‘It is important to highlight that exercise training and epinephrine did not completely prevent tumor formation, but induced a 50 percent reduction.

‘Thus, exercise training can never replace anti-cancer therapy, but could be an effective supportive strategy, which in addition to the biological effects, also has been shown to increase the patients’ quality of life and sense of empowerment.’  

Numerous population studies have shown that regular fitness can reduce a woman’s risk of breast cancer and, in those who already have breast cancer, may keep it from coming back. But few studies have examined how this works. 

RESULTS 

Hojman’s team used experimental mice implanted with human breast cancer tumors as well as tumor cells in test tubes to investigate how serum samples collected from healthy women and breast cancer patients before and after exercise affect the development of the breast tumor cells, and what mechanisms were involved.

They found that serum samples taken after exercise reduced the ability of tumor cells to grow in test tubes or in mice. 

Only 45 percent of mice with tumors steeped in post-exercise serum developed tumors, compared with 90 percent of mice with tumors not exposed to post-exercise serum or exposed to pre-exercise serum.

Progress: According to Cancer Research UK, nearly 80 per cent of female patients survive breast cancer for 10 or more years 

Progress: According to Cancer Research UK, nearly 80 per cent of female patients survive breast cancer for 10 or more years 

The researchers traced this anti-tumor activity to a rise in epinephrine and norepinephrine that occurs with moderately intense exercise and its effect on the a gene-signaling pathway known as Hippo that, among other things, helps to suppress tumor development.

EFFECTS 

This effect emerged only with serum samples taken after 15 minutes of moderate- to high-intensity exercise, according to the report in Cancer Research, and it was not related to the serum-donor’s body weight, blood sugar levels or immune responses.

‘In our study, we found that breast cancer patients in adjuvant chemotherapy, were indeed capable of performing the required exercise, so it is feasible for cancer patients to do the exercise training we are proposing,’ Hojman noted in an email interview.

‘Our identified mechanism of an epinephrine-driven regulation of the Hippo signaling pathway during exercise could certainly also be envisioned to work in other types of cancer,’ she said.

  

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