Pregnant women who are vaccinated against Covid are ‘significantly’ less likely to suffer a stillbirth compared to the unvaccinated, research suggests.
There had been widespread safety concerns about the jabs among expectant mothers, which saw them become one of the least vaccinated groups in the country.
Their fears were seized upon by anti-vaxx conspiracy theorists, who claimed the jabs were linked to stillbirths and other problems during pregnancy.
But British researchers who reviewed the findings of more than 20 studies involving 120,000 pregnant women found those who had the Pfizer or Moderna vaccine had a 15 per cent decreased risk compared to un-jabbed women.
The researchers suggested this finding may be down to unvaccinated pregnant women becoming more severely unwell with the virus, which could increase their risk of stillbirth.
And there was no difference in the rate of miscarriages, premature births or heavy bleeding during pregnancy between the vaccinated and unvaccinated.
The findings provide ‘much-needed assurance’ to women on the safety and benefits of getting jabbed when pregnant, the experts said.
A team of UK researchers, who reviewed more than 20 studies of 120,000 expectant mothers given mRNA vaccines, also found the jab is 90 per cent effective at preventing infection
The Pfizer or Moderna jabs were also not linked with any increase in adverse side effects for women or their babies, results showed
The meta-analysis looked at stillbirths when Delta was world-dominant.
So it’s not clear if the findings still apply to the milder Omicron variant.
UK health chiefs have long warned the vaccines do not cause any complications in pregnancy and unjabbed mothers were more likely to give birth preterm and their child is at greater risk of needing hospital care.
In early 2021 pregnant women were not offered the jab out of caution because trials had not yet examined whether the jab was safe and effective for them due to ethical reasons.
But in April 2021 the Joint Committee on Vaccination and Immunisation (JCVI), which advises No10 on the rollout, invited pregnant women to come forward after real world data from the UK and Israel threw up no causes for concern.
But uptake has remained sluggish among expectant mothers, with only half of pregnant women in England being vaccinated, citing unfounded concerns about the effect of the jab on their baby.
Researchers from St George’s, University of London and the Royal College of Obstetricians and Gynaecologists (RCOG) said there is an ‘immediate need’ for robust evidence to support pregnant people considering getting vaccinated.
They reviewed 23 studies which involved 117,562 women around the world who were fully jabbed during pregnancy or unvaccinated.
Almost all were vaccinated with mRNA jabs Pfizer or Moderna — the two used for the cohort in the UK.
The findings, published in the scientific journal Nature Communications, showed two doses of the mRNA jabs were 89.5 per cent effective at preventing infection seven days after the second dose.
And the risk of stillbirth was 15 per cent lower among vaccinated pregnant women, compared to the unvaccinated.
Jabbed pregnant women were no more likely to suffer miscarriage, give birth early or suffer placental abruption – when the placenta separates from the inner wall of the uterus before birth, the data showed.
And there was also no increased risk of the mother developing blood clots, heavy bleeding after birth or dying during pregnancy, while newborns were no more likely to have a low birth weight to be admitted to intensive care.
The risk of suffering an adverse outcome was either identical among both groups or up to 15 per cent lower.
Professor Asma Khalil, senior study author and an expert in obstetrics and maternal medicine at St George’s, said the findings should help address vaccine hesitancy in pregnant women.
He said: ‘Although many things are returning to normal, there is still a very clear and substantial risk of Covid infection for mothers and their babies, including an increased risk of premature birth and stillbirth.
‘It is essential that as many people as possible receive their vaccines to reduce the risk of complications during pregnancy.
‘This paper shows that Covid vaccination is both safe and effective and we hope that this will help to reassure pregnant people to take up their offer of a vaccine going forwards.’
Dr Edward Morris, president of the RCOG, said: ‘We know women have been hesitant about having the vaccine due to concerns over the effect on their baby.
‘We now have strong evidence to show that the vaccine does not increase the risk of adverse outcomes and is the best way of protecting both women and their babies.
‘We would recommend all pregnant women have the Covid vaccine and the booster vaccine.
‘Covid is still prevalent and if you do get the virus when you’re pregnant then you are at higher risk of severe illness.’
Current advice is for pregnant women to get vaccinated against Covid as soon as possible if they have not yet been jabbed and not to delay until after they give birth.
First and second Pfizer and Moderna jabs are offered to expectant mothers eight to 12 weeks apart, with a booster given three months after the second dose.
These vaccines do not contain live coronavirus and cannot infect a them or their unborn baby in the womb.
Dozens of studies have shown that Covid vaccines have no negative impact on pregnancy or the health of newborns.
But experts say vaccine hesitancy among expectant mothers was exacerbated by anti-vaxx disinformation and changing advice on whether pregnant women should be jabbed.
Expectant mothers were not included in initial clinical trials of the jabs – which is standard protocol for vaccines and other medicines – so health chiefs did not initially have enough evidence to recommend the jabs for the group.
And real world data shows catching Covid during pregnancy raises the risk of being hospitalised and admitted to intensive care, along with suffering stillbirth, pre-eclampsia and pre-term birth.
UK data shows almost every pregnant woman with Covid who needs hospital treatment or intensive care has not been vaccinated.
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