Global sea levels could rise as much as 10ft (3 metres) if the Thwaites Glacier in West Antarctica collapses.
Sea level rises threaten cities from Shanghai to London, to low-lying swathes of Florida or Bangladesh, and to entire nations such as the Maldives.
In the UK, for instance, a rise of 6.7ft (2 metres) or more may cause areas such as Hull, Peterborough, Portsmouth and parts of east London and the Thames Estuary at risk of becoming submerged.
The collapse of the glacier, which could begin with decades, could also submerge major cities such as New York and Sydney.
Parts of New Orleans, Houston and Miami in the south on the US would also be particularly hard hit.
A 2014 study looked by the union of concerned scientists looked at 52 sea level indicators in communities across the US.
It found tidal flooding will dramatically increase in many East and Gulf Coast locations, based on a conservative estimate of predicted sea level increases based on current data.
The results showed that most of these communities will experience a steep increase in the number and severity of tidal flooding events over the coming decades.
By 2030, more than half of the 52 communities studied are projected to experience, on average, at least 24 tidal floods per year in exposed areas, assuming moderate sea level rise projections. Twenty of these communities could see a tripling or more in tidal flooding events.
The mid-Atlantic coast is expected to see some of the greatest increases in flood frequency. Places such as Annapolis, Maryland and Washington, DC can expect more than 150 tidal floods a year, and several locations in New Jersey could see 80 tidal floods or more.
In the UK, a two metre (6.5 ft) rise by 2040 would see large parts of Kent almost completely submerged, according to the results of a paper published in Proceedings of the National Academy of Science in November 2016.
Areas on the south coast like Portsmouth, as well as Cambridge and Peterborough would also be heavily affected.
Cities and towns around the Humber estuary, such as Hull, Scunthorpe and Grimsby would also experience intense flooding.