A ‘trojan horse’ antibiotic which can trick its way through a superbug’s defences has been created by scientists.
The drug, called cefiderocol, works by attaching itself on to iron molecules which bacteria need to live and grow.
Once allowed inside the bacterial cell, it can destroy it from within, the researchers wrote in a prestigious medical journal.
Experts hope it will be the first of a number of new drugs developed to replace the world’s dwindling arsenal of antibiotics.
Antibiotic resistance is increasingly seen as the biggest threat to modern medicine, with warnings that drug-resistant infections will kill more people than cancer and diabetes by the middle of the century.
Scientists say a new antibiotic has proved effective against drug-resistant bacteria (stock)
The overuse of antibiotics has seen bacteria evolve to fight off conventional drugs, causing many to lose their power against infections.
Now scientists at Shionogi Inc, New Jersey, have developed cefiderocol, which is able to hijack the bacteria’s defences and get inside the cell.
It works by binding on to iron, which bacteria needs to survive, allowing the drug to pass through the bacteria’s filter system and cell walls.
Dr Simon Portsmouth, lead researcher of the trial, published in The Lancet, said: ‘Cefiderocol acts as a trojan horse.
‘The drug uses a novel mechanism of cell entry that takes advantage of the bacteria’s need for iron to survive.
‘During an acute infection, one of our innate immune responses is to create an iron-poor environment. In response, bacteria increase their iron intake.
‘Cefiderocol binds to irons and is transported through the extra outer membrane by the bacterium’s own iron-transport system.
‘These iron channels also enable the drug to bypass the bacteria’s porin channels and gain repeat entry even if the bacterium has evolved efflux pumps.’
Trials were carried out on 452 hospital patients with severe infections over a fortnight.
Two-thirds of patients were given cefiderocol three times a day, while the others received another strong antibiotic, called imipenem-cilastatin.
The new treatment was just as effective as the strong antibiotic with similar side effects.
Further research is now needed to test the medication against the most resistant superbugs, which even the last line of antibiotics are ineffective against.
Earlier this week, a report warned superbugs will kill more people than cancer and diabetes combined by 2050 without urgent action.
The more existing antibiotics are used, the more resistant bacteria become to them, with new drugs needed to turn the tide.
Writing an accompanying piece, Angela Huttner from the Division of Infectious Diseases at Geneva University Hospitals, said the early signs were promising.
She said: ‘The bacterium not only greets its destroyer at the door, it actively carries it across the threshold.
‘With such a clever entry design and an underlying mechanism of action that is tried and true, this new drug has generated enthusiasm.’
Professor Graham Cooke, NIHR Research Professor Imperial College London, said the results were encouraging.
‘We urgently need new classes of drugs, not just new drugs from the same family as existing ones.
‘This will give us treatment options for the increasing numbers of patients we see with resistant infections, particularly from Gram negative bacteria.’