Vapers who also smoke are twice as likely to suffer a stroke than adults who just stick to cigarettes, a study has warned.
Scientists analysed data on cigarette and e-cigarette use from 160,000 people in the US who were aged between 18 and 44.
Volunteers who both smoked cigarettes and vaped were much more likely to have a stroke, according to the research.
But the same results also revealed adults who only used e-cigarettes and had never smoked did not have an increased risk.
The findings suggest vaping is not a safe way of giving up tobacco, and could even harm the blood vessels, brain and heart.
Smoking cigarettes alone is already known to be a key risk factor for stroke because the killer habit thickens the blood.
The research suggests that vaping may not be a safe way to stop smoking and when combined with cigarettes has an even worse effect on hearts, brains and blood vessels
The research was led by George Mason University in Virginia and published in the American Journal of Preventive Medicine.
Lead investigator Tarang Parekh, department of health administration and policy, at George Mason University in America, said: ‘It’s long been known that smoking cigarettes is among the most significant risk factors for stroke.
‘Our study shows that young smokers who also use e-cigarettes put themselves at an even greater risk.
‘This is an important message for young smokers who perceive e-cigarettes as less harmful and consider them a safer alternative.
‘We have begun understanding the health impact of e-cigarettes and concomitant cigarette smoking, and it’s not good.’
Academics used data from the 2016-2017 Behaviour Risk Factor Surveillance System (BRFSS), a national annual, cross-sectional health survey conducted jointly by the Centres for Disease Control and Prevention and all US states and territories.
They analysed responses on cigarette and e-cigarette use from 161,529 participants aged 18 to 44 years old.
The study calculated the adjusted odds ratios (AORs) for cerebrovascular events among the smokers.
The researchers accounted for frequency of use, demographic factors, hypertension, diabetes, and cholesterol levels, body mass index, physical activity, and alcohol use when calculating the odds of stoke.
It suggests the AOR for stroke among those with current sole tobacco use was 1.59, and current vapers who were former cigarette users had an AOR of 2.54.
The odds were almost three times higher those who use both cigarettes and e-cigarettes versus non-smokers.
Compared with current tobacco smokers, vapers had lower odds of stroke (0.43), the research suggests.
The study did not find that switching from cigarettes to e-cigarettes had any clear benefit because it didn’t adjust the odds of suffering a stroke.
Dr Lion Shahab of University College London, cautioned that it was not clear whether dual use of e-cigarettes, or switching to e-cigarettes from cigarettes, was a result of stroke or preceded it.
He added that the findings indicate an ‘additive harmful effect of e-cigarettes on smokers’ blood vessels, hearts and brains’.
Dr Shahab, senior lecturer in epidemiology and public health at UCL, said: ‘While this paper highlights the need to continue studying the potential health effects of e-cigarette use, the results should be interpreted with caution as the observed associations may be simply due to unmeasured confounding and reverse causality.
‘It is entirely possible that the group of current or former smokers took up e-cigarettes precisely because they had a health scare, which would result in the observed association.’
Smoking increases the risk of stroke because the chemicals thicken the blood, increasing the risk of blood clots and narrowing the arteries, as well as restricting oxygen in the blood.
It is unclear how e-cigarettes, which still contain some chemicals, impact the heart and circulation, or other aspects of health. But they are not considered completely harm-free.
Previous research in mice, by University of Texas El Paso, found short-term exposure to the vaping devices appeared to increase the risk of clot formation, which can lead to a stroke or heart attack.
And research on blood cells at Stanford University found the flavourings in e-cigarettes caused DNA damage, cell death and inflammation.
Experts believe this damage to the cells which line blood vessels causes them to harden and form clots, suggesting heavy use of vaping could increase someone’s danger of a heart attack or stroke.
The latest study comes as health officials in the US investigate a spate of vaping related illnesses across the states.
Vaping-related lung injuries have killed 55 Americans and sent more than 2,500 people to the hospital, figures show.
Officials have identified Vitamin E acetate and THC as a cause of concern. These are not found in regulated products in the UK.
Public Health England say vaping is 95 per cent safer than smoking and e-cigarettes are twice as effective at helping smokers to quit compared with nicotine replacement therapy (NRT).
Some 3.6million people in the UK are vaping, research by the charity Action on Smoking and Health (Ash) found.
At the same time, figures show an accelerated drop in smoking rates, currently at a record low of 14.9 per cent in England.