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Will Ferrell and John C. Reilly reunite in rollicking trailer for comedy Holmes And Watson

They delighted audiences in the 2008 comedy Step Brothers.

And a decade later, Will Ferrell and John C. Reilly are together again for the upcoming Victorian era comedy Holmes And Watson.

In a rollicking trailer that dropped Friday, Will spoofs Arthur Conan Doyle’s legendary fictional detective and John sends up his assistant Dr. John Watson.

Side by side: A decade after Step Brothers, Will Ferrell (right) and John C. Reilly (left) are together again for the upcoming Victorian era comedy Holmes And Watson

The trailer opens with the dynamic duo being introduced to their sovereign, Queen Victoria, who is played by Pam Ferris of Harry Potter and Matilda fame.

When they are presented to Her Majesty, Holmes bows respectfully, but Watson gets flustered, grabbing her hand and blurting out: ‘I love you!’

‘Watson!’ Holmes hisses, as the queen wrenches her hand haughtily away and storms off, leaving the two men to themselves.

Who's who: In a rollicking trailer that dropped Friday, Will spoofs Arthur Conan Doyle's legendary fictional detective and John sends up his assistant Dr. John Watson

Who’s who: In a rollicking trailer that dropped Friday, Will spoofs Arthur Conan Doyle’s legendary fictional detective and John sends up his assistant Dr. John Watson

Glam: The trailer opens with the dynamic duo being introduced to their sovereign, Queen Victoria, who is played by Pam Ferris of Harry Potter and Matilda fame

Glam: The trailer opens with the dynamic duo being introduced to their sovereign, Queen Victoria, who is played by Pam Ferris of Harry Potter and Matilda fame

Bit much: When they are presented to Her Majesty, Holmes bows respectfully, but Watson gets flustered, grabbing her hand and blurting out: 'I love you!'

Bit much: When they are presented to Her Majesty, Holmes bows respectfully, but Watson gets flustered, grabbing her hand and blurting out: ‘I love you!’

Aghast: 'Watson!' Holmes hisses, as the queen wrenches her hand haughtily away and storms off, leaving the two men to themselves

Aghast: ‘Watson!’ Holmes hisses, as the queen wrenches her hand haughtily away and storms off, leaving the two men to themselves

‘Whew,’ says Holmes, prompting Watson to remark: ‘What a looker, right?’ and Holmes to reply: ‘She is stunning!’

A voiceover introduces Sherlock Holmes, explaining that ‘His methods are ingenious’ as he is seen dusting a glass of whiskey for fingerprints.

‘He’s a master of disguise,’ says the voiceover, as Holmes, standing next to Watson, pastes an obviously false handlebar mustache onto his face.

Gobsmacked: 'Whew,' says Holmes, prompting Watson to remark: 'What a looker, right?' and Holmes to reply: 'She is stunning!'

Gobsmacked: ‘Whew,’ says Holmes, prompting Watson to remark: ‘What a looker, right?’ and Holmes to reply: ‘She is stunning!’

Look closely: A voiceover introduces Sherlock Holmes, explaining that 'His methods are ingenious' as he is seen dusting a glass of whiskey for fingerprints

Look closely: A voiceover introduces Sherlock Holmes, explaining that ‘His methods are ingenious’ as he is seen dusting a glass of whiskey for fingerprints

Ingenious: 'He's a master of disguise,' says the voiceover, as Holmes, standing next to Watson, pastes an obviously false handlebar mustache onto his face

Ingenious: ‘He’s a master of disguise,’ says the voiceover, as Holmes, standing next to Watson, pastes an obviously false handlebar mustache onto his face

‘What have you done with Sherlock?’ Watson demands, drawing his gun, only for Holmes to rip off the mustache and say: ‘Why, Watson, I never left.’

The voiceover explains that Holmes’ ‘mind is brilliant,’ while Holmes lifts a cricket bat and perfectly calibrates his swing to kill a mosquito fluttering nearby.

As he takes aim, imaginary chalk drawings appear onscreen showing Holmes’ mental calculations – in a dig at a similar device used on the hit BBC series Sherlock.

Armed and dangerous: 'What have you done with Sherlock?' Watson demands, drawing his gun, only for Holmes to rip off the mustache and say: 'Why, Watson, I never left'

Armed and dangerous: ‘What have you done with Sherlock?’ Watson demands, drawing his gun, only for Holmes to rip off the mustache and say: ‘Why, Watson, I never left’

Ready to strike: The voiceover explains that Holmes' 'mind is brilliant,' while Holmes lifts a cricket bat and perfectly calibrates his swing to kill a mosquito fluttering nearby

Ready to strike: The voiceover explains that Holmes’ ‘mind is brilliant,’ while Holmes lifts a cricket bat and perfectly calibrates his swing to kill a mosquito fluttering nearby

Tip of the hat: As he takes aim, imaginary chalk drawings appear onscreen showing Holmes' mental calculations - in a dig at a similar device used on the hit BBC series Sherlock

Tip of the hat: As he takes aim, imaginary chalk drawings appear onscreen showing Holmes’ mental calculations – in a dig at a similar device used on the hit BBC series Sherlock

Unfortunately, he smashes the mosquito dead against the glass around a killer bee colony, which proceeds to shatter and release the bugs.

Then, while Holmes and Watson attend a soiree at Buckingham Palace with the Queen, a bomb goes off in a ballroom.

At least one person is left dead, and Watson discovers a note let by the killer reading: ‘Solve this case in four days or I will kill the Queen.’

Whoops: Unfortunately, he smashes the mosquito dead against the glass around a killer bee colony, which proceeds to shatter and release the bugs

Whoops: Unfortunately, he smashes the mosquito dead against the glass around a killer bee colony, which proceeds to shatter and release the bugs

Trouble: Then, while Holmes and Watson attend a soiree at Buckingham Palace with the Queen, a bomb goes off in a ballroom

Trouble: Then, while Holmes and Watson attend a soiree at Buckingham Palace with the Queen, a bomb goes off in a ballroom

Next in line: At least one person is left dead, and Watson discovers a note let by the killer reading: 'Solve this case in four days or I will kill the Queen'

Next in line: At least one person is left dead, and Watson discovers a note let by the killer reading: ‘Solve this case in four days or I will kill the Queen’

The note is from Holmes’ iconic rival Dr. James Moriarty, who in this movie is played by Pam’s fellow old Harry Potter hand Ralph Fiennes.

‘Come, Watson, we have a killer to catch,’ says Holmes at one point – to which a street urchin utters the immortal saying: ‘No s***, Sherlock!’

Holmes and Watson come into contact with Dr. Grace Hart, played by Rebecca Hall, and her associate Minnie, played by Lauren Lapkus.

Star power: The note is from Holmes' iconic rival Dr. James Moriarty, who in this movie is played by Pam's fellow old Harry Potter hand Ralph Fiennes

Star power: The note is from Holmes’ iconic rival Dr. James Moriarty, who in this movie is played by Pam’s fellow old Harry Potter hand Ralph Fiennes

Origin story: 'Come, Watson, we have a killer to catch,' says Holmes at one point - to which a street urchin utters the immortal saying: 'No s***, Sherlock!'

Origin story: ‘Come, Watson, we have a killer to catch,’ says Holmes at one point – to which a street urchin utters the immortal saying: ‘No s***, Sherlock!’

Meeting their match: Holmes and Watson come into contact with Dr. Grace Hart, played by Rebecca Hall (right), and her associate Minnie, played by Lauren Lapkus (left)

When Hart suggests an autopsy on the murder victim, Holmes exclaims: ‘A woman doctor? Impossible! Fortunately, we have a real doctor here.’

He gestures to a smiling Watson, who gives a little bow and says with perfect gentlemanly gallantry: ‘Would you like some heroin?’

Brief clips show supporting performances by Hugh Laurie as Holmes’ brother Mycroft and Steve Coogan in a currently undisclosed part.

Dripping with condescension: When Hart suggests an autopsy on the murder victim, Holmes exclaims: 'A woman doctor? Impossible! Fortunately, we have a real doctor here'

Dripping with condescension: When Hart suggests an autopsy on the murder victim, Holmes exclaims: ‘A woman doctor? Impossible! Fortunately, we have a real doctor here’

Chivalry: He gestures to a smiling Watson, who gives a little bow and says with perfect gentlemanly gallantry: 'Would you like some heroin?'

Chivalry: He gestures to a smiling Watson, who gives a little bow and says with perfect gentlemanly gallantry: ‘Would you like some heroin?’

Star turns: Brief clips show supporting performances by Hugh Laurie as Holmes' brother Mycroft (pictured) and Steve Coogan in a currently undisclosed part

Star turns: Brief clips show supporting performances by Hugh Laurie as Holmes’ brother Mycroft (pictured) and Steve Coogan in a currently undisclosed part

At one point, Watson takes a 19th century camera on a tripod and manages to use it as a selfie stick in order to snap himself with Holmes and the Queen.

Unfortunately, though, when they move around to shift the photo into an area with better lighting, Watson accidentally swings the camera into his sovereign’s head.

The Queen falls to the floor unconscious, hitting her head against a table on the way down, to the horror of her two subjects.

Written and helmed by Get Hard director Etan Cohen, who was also a writer on Tropic Thunder, Holmes And Watson is slated for release December 21.

Period piece: At one point, Watson takes a 19th century camera on a tripod and manages to use it as a selfie stick in order to snap himself with Holmes and the Queen

Period piece: At one point, Watson takes a 19th century camera on a tripod and manages to use it as a selfie stick in order to snap himself with Holmes and the Queen

Oops: Unfortunately, though, when they move around to shift the photo into an area with better lighting, Watson accidentally swings the camera into his sovereign's head

Oops: Unfortunately, though, when they move around to shift the photo into an area with better lighting, Watson accidentally swings the camera into his sovereign’s head

Out cold: The Queen falls to the floor unconscious, hitting her head against a table on the way down, to the horror of her two subjects

Out cold: The Queen falls to the floor unconscious, hitting her head against a table on the way down, to the horror of her two subjects

Incoming: Written and helmed by Get Hard director Etan Cohen, who was also a writer on Tropic Thunder, Holmes And Watson is slated for release December 21

Incoming: Written and helmed by Get Hard director Etan Cohen, who was also a writer on Tropic Thunder, Holmes And Watson is slated for release December 21

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