Restricting calories can delay aging, says researcher

Fasting can delay aging, a researcher has claimed on the back of ‘promising’ trials into the controversial fad of restricting calories.

Dr Rozalyn Anderson, co-editor of a gerontology journal, claimed people are often unaware of the ‘amazing fact’ that wrinkles aren’t inevitable.

She pointed to a landmark study earlier this year which showed adults age 0.6 years slower if they eat 25 per cent less calories each day.

This is the equivalent of a grown man sticking to 1,875 calories over a 24-hour period or 1,500 for a woman – if guidelines are taken into account.

The groundbreaking results were published in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, which Dr Anderson edits.

Dr Rozalyn Anderson, co-editor of a gerontology journal, claimed people are often unaware of the ‘amazing fact’ that wrinkles aren’t inevitable

She said: ‘Remarkably, caloric restriction (CR) has been shown to be effective in delaying aging in multiple species and the results in humans look equally promising.

‘Indeed for many studies, CR is used as the gold-standard for enhanced longevity against which new drugs and anti-aging strategies are measured.’

Her comments were published in the journal’s latest special issue, which focused heavily on restrictive diets that target the biology of aging.

The issue contains an array of studies, involving mice and humans, looking at the effects of fasting throughout the day.

Dr Anderson, who leads the Metabolism of Aging Research Program at the University of Wisconsin-Madison, praised the research.

She said: ‘Ultimately what these studies show is that what you eat influences how you age, and it’s not all bad news.’

AGING CAN BE REVERSED, STUDY REVEALS ON RATS

It’s something that many have only dreamed of.

But now scientists believe they may have found a way to reverse the signs of aging.

Researchers at the University of Kentucky in Lexington were able to back-track the inevitable process and prevent memory decline in rats.

Published in The Journal of Neuroscience, the study showed that preventing wrinkles could be as easy as expressing a protein called FKBP1b.

The protein regulates calcium levels in the hippocampus – a region of the brain that is considered responsible for memory.

The research involved injecting rats, which are deemed medically similar to humans, with the experimental protein.

It was found to stop cognitive decline in rats given the treatment at 13 months – before memory is hampered by old age.

And in those rodents who were injected when the deterioration kicked in, the mental decline – similar to that of dementia – was reversed.

A separate analysis also revealed how the FKBP1b treatment restored activity in 876 genes thought to switch off in old age.

Further tests showed the levels of expression in these genes were similar to that in younger rats who weren’t given treatment.

‘One of the things that people sometimes miss is the amazing fact that aging can be altered; caloric restriction research proves this.’

Scientists first stumbled across the longevity effect of reducing calories more than 80 years ago in studies on rodents.

Advances in technology have allowed scientists to make even further progress in confirming the links with the widely criticised diets.

Concerns have been raised in recent years that the diet can actually have the opposite effect – by slowing down metabolism. 

And critics also believe restricting calories can lead to fatigue, nutrient deficiencies and even harm fertility in men and women. 

She pointed to a landmark study earlier this year which showed adults age 0.6 years slower if they eat 25 per cent less calories each day

She pointed to a landmark study earlier this year which showed adults age 0.6 years slower if they eat 25 per cent less calories each day

But studies have repeatedly found the diet to lower the risk of killer diseases including cancer, heart disease and even diabetes.

A study published in May, called CALERIE, showed the most stark effects of a low calorie diet on lifespan.

Those on the controvesial diet saw their biological age increase by 0.11 years. In contrast, those eating normally aged by 0.71 years.

Dr Anderson was also behind promising research in January that revealed fasting in middle age can help people to live longer.

Restricting the food we put into our bodies appears to make them more able to fight off the illnesses that accompany old age, the study found. 

‘Cutting your calories delays ageing, probably because the body uses energy from food differently to become more resilient,’ she said at the time.

‘By targeting aging itself we could, instead of fighting cancer or cardiovascular disease individually, target the full spectrum of disease simultaneously.’

And previous research from the same university found rhesus monkeys given 20 per cent less food lived nine years beyond the average lifespan. 

WANT TO LOSE WEIGHT? EAT CHEESE, SOY BEANS AND BEEF 

Eating cheese, soy beans and beef could help you to lose weight, new research suggests.

The findings offer hope of a diet that helps to battle bulging waistlines without relying on restricting calories. 

University of Wisconsin-Madison researchers warned calorie restricted diets are notoriously difficult to stay on top of.

Many aspiring slimmers attempting the controversial diet succumb to temptation out of sheer hunger – leading to no weight loss.

But the new study, published in the Journal of Physiology, shows there is hope for those desperate to stay slim in the coming months.

It revealed consuming three specific amino acids – known as the building blocks for protein – ‘promoted leanness’ in obese mice. 

They were leucine, isoleucine and valine. All three can be found in high quantities in cheese, soy beans and beef.

The findings, which need to be backed up on humans, remained consistent even when the mice were fed the same amount of calories. 

Dr Dudley Lamming, one of the lead investigators, revealed the amino acid diet has strongest benefits for controlling blood sugar.



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