She just announced her shock split from Justin Theroux.
But before her relationship with her now estranged husband began, Jennifer Aniston, 49, was linked to some of the biggest stars in Hollywood.
From her high profile marriage to Brad Pitt to her relationship with John Mayer, it’s time to take a look back at Aniston’s famous exes.
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Happier times: Jennifer Aniston and Justin Theroux announced their separation Thursday (pictured April 2017)
Aniston and Theroux announced they would be splitting after more than two years of marriage on Thursday.
While this was the second marriage for Aniston, who was previously wed to Pitt, it is the first time Theroux, 46, has tied the knot.
The actress received a proposal from Theroux on his birthday in August 2012.
Starter marriage: Brad Pitt with Jennifer in September 2004 – four months before they split after five years of marriage
In August 2012 Theroux’s spokesperson confirmed: ‘Justin Theroux had an amazing birthday on Friday, receiving an extraordinary gift when his girlfriend, Jennifer Aniston, accepted his proposal of marriage.’
It came just over a year after the former Friends actress started dating Theroux in May 2011 while filming the 2012 film Wanderlust, having met years earlier.
Aniston was previously married to Brad Pitt for five years from 2000 to 2005.
They announced their split in January 2005, with Brad being photographed with Angelina Jolie in April of that year.
Of course Jolie, Pitt and Aniston proved to be one of the most buzzed about Hollywood love triangles of all time. Their romance was infamously shrouded in whispers that they embarked on a relationship while Brad was still married to Jennifer – having met on the set of Mr & Mrs Smith in 2004.
In a 2012 interview with Vogue, Jolie- who married Pitt last year – spoke for the first time about meeting Pitt on the set of Mr & Mrs Smith in 2004, a year before he split from Aniston.
Romance: The couple started dating in 2011 after co-starring in the 2012 film Wanderlust
She confessed: ‘Because of the film, we ended up being brought together to do all these crazy things, and I think we found this strange friendship and partnership that kind of just suddenly happened.
‘I think a few months in I realized, “God, I can’t wait to get to work.”… Anything we had to do with each other, we just found a lot of joy in it together and a lot of real teamwork. We just became kind of a pair.’
Jolie added: ‘It took until, really, the end of the shoot for us, I think, to realize that it might mean something more than we’d earlier allowed ourselves to believe. And both knowing that the reality of that was a big thing, something that was going to take a lot of serious consideration.’
Following Aniston’s four and a half year marriage to Pitt, which saw them separate in January 2005, she endured a string of fling flops.
‘Defibrillator’: Jennifer praised Vince Vaughn for ‘bringing me back to life’ after her gruelling divorce
Aniston was seen on the arm of The Break-Up co-star Vince Vaughn soon after, before moving on to British model Paul Sculfor for a few months in 2007 and later had an on/off romance with John Mayer.
Meanwhile, Theroux fell under the microscope during his courting of Aniston – as he broke up with his long-term girlfriend of 14 years, Heidi Bivens.
The well-respected fashion stylist, who has worked at Details and Vogue, was said to be ‘blindsided’ by his actions.
But it seems Jennifer certainly made Justin sweat, reportedly turning down his initial proposal in June 2012 during a romantic European jaunt in Paris and Rome.
In 2013, just a year after Theroux had proposed to her with an eight-carat diamond ring, Aniston told the Associated Press that they already ‘felt married’.
She said: ‘We just want to do it when it’s perfect, and we’re not rushed, and no one is rushing from a job or rushing to a job And, you know, we already feel married.’
Aniston and Theroux announced their separation Thursday.
The decision to split ‘was mutual and lovingly made at the end of last year’, according to a statement released on Thursday through her publicist.
The Friends star became engaged to the Leftovers actor, 46, in August 2012, and they married in a surprise ceremony at their LA home on August 5, 2015.
End of an era: Justin reportedly ‘dumped’ Heidi Bivens, his girlfriend of 14 years, to be with Jennifer
Secret wedding: Jennifer and Justin’s nuptials were held at their Bel Air home in 2015