Intermittent fasting – one of the most popular and promoted dieting techniques – may actually raise the risk of an early death.
A study of 24,000 Americans over 40 found those who ate one meal per day were 30 per cent more likely to die from any cause in 15 years than those who ate three.
Intermittent fasting – which means eating within a strict time window or skipping meals entirely – became one of hottest diet tools in the early 2010s.
A-list celebrities such as Kourtney Kardashian, Mark Wahlberg, Hugh Jackman and Jennifer Aniston say it helps them lose weight or detox their bodies.
Ironically, one of the main benefits cited by followers of the diet is longevity. It had previously been linked to a lower risk of multiple diseases.
In the latest study, skipping breakfast was linked to a higher risk of dying from heart disease, while missing lunch or breakfast appeared to raise the chance of all-cause mortality.
The results remained even if people exercised, ate healthily and rarely smoked or drank alcohol, the researchers claim.
They say fasters usually end up consuming a relatively large amount of food in one go, which over time may damage the body’s cells.
The team caution it is still too early to say definitively that fasting played a role in the early deaths as they can’t rule out other lifestyle and genetic factors.
Intermittent fasting – one of the most popular and promoted dieting techniques – may actually raise the risk of an early death (stock)
Jennifer Aniston (right) and Nicole Kidman (left) are two celebrities who are reported to have used intermittent fasting
Pictured above is Mark Wahlberg’s daily routine, which involves fasting for 18 hours
The latest study, by researchers from the University of Tennessee, found that three meals per day was the sweet-spot for a longer life.
But the research found that eating them too close together was also linked to an increased risk of an early death.
Like their theory with fasting, the team believe eating too much too quickly puts metabolic strain on the body.
Lead author of the new study Professor Yangbo Sun, from the University of Tennessee, said: ‘At a time when intermittent fasting is widely touted as a solution for weight loss, metabolic health, and disease prevention, our study is important for the large segment of American adults who eat fewer than three meals each day.
‘Our research revealed that individuals eating only one meal a day are more likely to die than those who had more daily meals.
‘Among them, participants who skip breakfast are more likely to develop fatal cardiovascular diseases, while those who skip lunch or dinner increase their risk of death from all causes.’
She added: ‘Based on these findings, we recommend eating at least two to three meals spread throughout the day.’
In the study, published in the Journal of Academy of Nutrition and Diabetics, her team analyzed data from 24,011 over-40s from across the US.
They were already participants in a nationally representative survey which ran from 1999 to 2014 and asked them about diet, general health, disease and behaviors every two years. Forty percent of participants ate fewer than three meals a day, on average.
Their survey answers were linked up to their medical records. Overall there were 4,175 deaths by the end of the study, including 878 caused by heart problems.
Compared with participants who ate three meals per day, consuming just one meal was linked to a 30 per cent increased risk of all-cause mortality and 83 per cent raised risk of heart disease death.
People who skipped breakfast were at a 40 per cent increased risk of heart disease death compared to those who did not, but there was no difference in all-cause mortality.
However, people who missed out lunch or dinner were 12 to 16 per cent more likely to die for any reason.
Meanwhile, people who ate three meals per day but had an average gap of fewer than four-and-a-half hours between at least two of those had a 17 per cent increased risk of all-cause mortality, compared to people who spaced their meals out by five or more hours.
Senior study author Dr Wei Bao, an epidemiologist at the University of Iowa, said: ‘Our results are significant even after adjustments for dietary and lifestyle factors (smoking, alcohol use, physical activity levels, energy intake, and diet quality) and food insecurity.
‘Our findings are based on observations drawn from public data and do not imply causality. Nonetheless, what we observed makes metabolic sense.’
Dr Bao explained that skipping meals usually means ingesting a larger energy load at one time, which can aggravate the burden of glucose metabolism regulation and lead to subsequent metabolic deterioration.
This can also explain the association between a shorter meal interval and mortality, as a shorter time between meals would result in a larger energy load in the given period.
Dr Bao added: ‘Our research contributes much-needed evidence about the association between eating behaviors and mortality in the context of meal timing and duration of the daily prandial period.’