Interview with the world’s first ‘test tube baby’

The world’s first test tube baby has said she hopes families who undergo cutting-edge fertility treatments – such as ‘three parent’ babies – are not subject to the same harassment her family received after pioneering IVF.

Louise Brown’s family was bombarded with hate mail after she was born.

In an interview with the Press Association, Ms Brown said she is still subject to ‘cruel and ill-informed’ comments online from time to time.

She added she hopes people who undergo today’s pioneering fertility treatments – such as mitochondrial replacement therapy – do not suffer the same barrage of negativity.

In an interview with the Press Association, Louise Brown said she is still subject to ‘cruel and ill-informed’ comments online from time to time

On November 10 1977, exactly 40 years ago, Lesley Brown, who with husband John had been trying to conceive for nine years, fell pregnant after undergoing in-vitro fertilisation.

Nine months later, Louise was born – the first baby born following IVF.

Six million babies have been born thanks to the technique, pioneered by British scientist Robert Edwards and his obstetrician colleague Patrick Steptoe.

Ms Brown, a clerk at a freight company, said: ‘People put cruel and ill-informed comments on the internet just about whenever there is a story about me. But I just ignore it.’

Asked whether she thought families who use the ‘three-person baby’ technique will get similar mail, she replied: ‘I hope they don’t.’

The world’s first three-parent baby was born last year. Abrahim Hassan, whose Jordanian mother was treated by a US team in Mexico, was conceived from an egg containing DNA from his mother and father, and a tiny amount of mitochondrial DNA from a third person – a female donor.

The aim was to prevent Abrahim inheriting defective mitochondria, rod-like batteries in cells, that could give him Leigh syndrome – a fatal nervous system disorder.

Earlier this year doctors at the Newcastle Fertility at Life clinic were awarded the first official licence to create a baby with three genetic parents.

Ms Brown's birth in July 1978 was exclusively revealed in the Daily Mail with the headline: 'And here she is… The lovely Louise'

Ms Brown’s birth in July 1978 was exclusively revealed in the Daily Mail with the headline: ‘And here she is… The lovely Louise’

Six million babies have been born thanks to the technique, pioneered by British scientist Robert Edwards and his obstetrician colleague Patrick Steptoe

Six million babies have been born thanks to the technique, pioneered by British scientist Robert Edwards and his obstetrician colleague Patrick Steptoe

Ms Brown’s sons Cameron, 10, and Aiden, four were conceived naturally. Aiden’s middle names are Patrick Robert after Mr Steptoe and Mr Edwards.

The 39-year-old also hit out at rationing in the NHS.

‘I am not an expert on IVF but I do believe it should be available to as many people as possible,’ she said.

ANOTHER VICTIM OF THE IVF CLAMPDOWN

The county that pioneered IVF 40 years ago is the latest victim of the clampdown on fertility treatment offered freely on the NHS.

Health chiefs in the Cambridgeshire and Peterborough area stopped giving infertile women the service with immediate effect in September.

The decision, which attracted huge backlash, is expected to save the clinical commissioning group (CCG) £700,000.

It follows similar controversial decisions made by cash-strapped boards in Croydon and a part of Essex as they react to NHS budget cuts. 

‘Earlier this year I attended an event in the European Parliament in Brussels, which looked at infertility in nine countries across the EU.

‘It showed there is a huge difference in what treatment is available to you and how much it costs, depending on where you live.

‘The same is true across the UK. Infertility affects one in six couples and my view is that you should get the same treatment wherever you live.’

Data released last week by the campaign group Fertility Fairness showed that the number of local health bodies offering the recommended three NHS-funded cycles of IVF has halved in the last five years and stands at 12 per cent.

Mrs Brown said her parents, who have both since died, ‘just wanted to have a baby’.

‘Like millions of other couples with fertility problems they were prepared to do pretty much anything to have a baby,’ she added.

‘They didn’t really see themselves as pioneers at the time, but the older I get the more I appreciate what they went through to have me.’

On her work with the fertility community – including writing a book on her experience – she added: ‘I’m always pleased to meet those involved in IVF, couples looking for treatment and of course the babies that have been born through IVF.

‘Sometimes it is scary to think that my birth led to all this, but I try not to think about it too much. I have never known anything different.’ 

IVF: THE FACTS 

What is IVF?

In vitro fertilisation (IVF) is probably the best-known technique for helping people with fertility problems have a baby.

During the process, an egg, or multiple eggs, are removed from a woman’s ovary and fertilised with sperm in a laboratory.

The fertilised egg is then returned to the woman’s womb to grow and develop.

Who uses it?

It is most commonly used with couples who are having fertility problems.

Others who can use the technique include same sex couples or single women.

NHS Choices estimates that around one in seven couples in the UK have trouble conceiving – around 3.5 million people in Britain.

What causes infertility?

Fertility problems can affect either men or women. In one in four cases, it isn’t possible to determine the cause.

In women, common causes of infertility include: ovulation problems, issues with fallopian tubes or a condition called endometriosis.

How successful is IVF?

IVF success rates depend on how old the woman undergoing treatment is.

According to NHS Choices, in 2010 the percentage of IVF treatments that resulted in a live birth was; 32.2% for women under 35, 27.7% for women aged 35 to 37, 20.8% for women aged 38 to 39, 13.6% for women aged 40 to 42, 5% for women aged 43 to 44.

Are there any risks?

There are risks associated with IVF which include side effects from the medication, ovarian hyperstimulation syndrome, multiple births and ectopic pregnancies. Treatments can also take their toll on mental wellbeing.

Can I get it on the NHS?

The National Institute for Health and Care Excellence recommends that eligible patients should have access to three rounds of IVF funded through the NHS.

But just 12% of local health bodies offer this many cycles – others offer one or two cycles and some offer none at all.

How much does it cost privately?

Costs vary but they can be around £5,000 for one cycle.

How many babies have been born using the technique?

Estimates suggest that around six million babies have been born around the world using the technique. 

Data from the Human Fertilisation and Embryology Authority (HFEA) show that between 1991 and 2015 more than 300,000 children have been born in the UK over the last quarter of a century thanks to IVF and donor insemination.

By the end of 2015, the number of cycles of in vitro fertilisation cycles carried out since 1991 stood at 1,034,601, according to the HFEA. 

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