Man with high levels of pregnancy hormone is diagnosed with ‘exceptionally rare’ cancer

By SADIE WHITELOCKS FOR DAILYMAIL.COM

Published: 19:48 BST, 2 April 2025 | Updated: 19:52 BST, 2 April 2025

It’s an extremely rare form of cancer that usually blights pregnant women. 

But doctors have revealed how a male patient developed choriocarcinoma – which traditionally starts in the uterus – in his testicles, making it an even rarer form of the disease.

It is so rare, there are only a handful of reports of men with the condition.  

The unnamed 52-year-old man did not know he had the disease and he originally visited a doctor complaining of a painless swelling in the lower right side of his abdomen, in the area where the hip meets the thigh. 

He said the swelling had progressively increased in size over a three-month period and during a physical examination, doctors discovered it extended into his scrotum. 

Other symptoms of choriocarcinoma can include breast feminization, shrinking testes, and a loss of libido. However, the only complaint the man presented was abdominal swelling.

After an initial check up, he was referred to a urologist for further testing and specialists found he had extremely high levels of beta-hCG, which is a hormone produced by the placenta after a fertilized egg implants in the uterus.

The man’s beta-hCG levels ranged from 236 to 335 IU/L, which is roughly the same range as a woman who is four weeks pregnant. 

Doctors have revealed how a male patient developed choriocarcinoma – which traditionally starts in the uterus – in his testicles, making it an even rarer form of the disease (stock image)

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Men do produce small amounts of beta-hCG, but it is not one of their primary hormones and it is most known for its role in pregnancy.

In non-pregnant women, beta-hCG levels are usually less than 5 IU/L, while for healthy men, it is less than 2 IU/L.

Further scans of the patient’s abdomen and pelvis revealed that he had testicular choriocarcinoma, which had spread to to the lymph nodes, liver, lungs and bones.

Dr Abdelkader Chaar, an internist who has investigated testicular choriocarcinomas, describes them as the ‘most aggressive and rapidly arising germ cell tumors’. 

He says by the time most cases are diagnosed, the cancer has already spread to other parts of the body. 

It is estimated that 9,720 new cases of testicular cancer will be diagnosed in 2025 in the US. 

Of these, Dr Chaar says choriocarcinomas will represents less than two percent of cases.

After being diagnosed with testicular choriocarcinoma, the unidentified patient underwent six cycles of chemotherapy in an effort to shrink the tumor. 

He then underwent surgery to have his testicles removed before more chemotherapy treatments. 

Despite initially responding well to the treatments, the man started experiencing seizures two months after his surgery. 

Subsequent CT scans revealed that the cancer had spread to his brain. 

Ten months after his diagnosis the man, who was married and had three children, passed away due to the disease. 

The case was reported by a team of doctors from Jalan Hospital in Malaysia. 

They conclude, in a paper published in the American Journal of Case Reports: ‘Testicular choriocarcinoma poses a significant clinical challenge due to its rarity and aggressiveness. 

‘Individualized and multidisciplinary management approaches are essential for effectively addressing this challenging condition.’

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Man with high levels of pregnancy hormone is diagnosed with ‘exceptionally rare’ cancer

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