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New drug ‘forces body to burn fat and keep slim even on unhealthy diet’

Obesity could be stopped with a world-first pill which stops the body producing fat cells, a study has claimed.

Scientists have invented a drug which stops the fat-creating process in the body, which they say could help tackle heart disease, cancer and dementia.

In a study on mice, the animals given the drug managed to stay slim even when they ate high-fat foods.

The pill – named PO53 – causes fats like cholesterol to be burned up by muscles instead of building up in the body, and experts hope it will also work in humans.

As nearly a quarter of people around the world are expected to be obese by 2045, researchers have hailed their findings a ‘major step forward’ in tackling the crisis.

A drug which blocks a process in the body which creates fat cells could help to cut rates of cancer, heart disease, type 2 diabetes and dementia, according to Australian researchers

Scientists at the University of New South Wales in Sydney, Australia, began their experiment to try and find a way to prevent type 2 diabetes.

The condition is triggered by obesity, but is caused by resistance to the blood-sugar controlling hormone insulin.

But instead of affecting blood sugar, the drug created by the scientists stopped the mice’s bodies developing body fat.

Researchers say their discovery is the first time scientists have managed to stop this process. 

Reducing obesity could cut cancer and heart disease deaths 

Now, they say, the pill could have much bigger implications and cutting down obesity rates could reduce people’s risk of getting type 2 diabetes, cancer, heart disease and dementia, all of which are more likely to affect fat people.

One of the study’s authors, Professor Nigel Turner said:’Since obesity is a strong risk factor for many different diseases including cardiovascular disease and cancer, any new therapy in this space could have widespread benefits.’

The drug works by blocking an enzyme called ceramide synthase 1 (CerS1).

Drug makes body burn fat instead of storing it 

When this enzyme is stopped by the PO53 drug the body burns up fats like cholesterol and triglycerides, which come from foods, in muscles instead of storing them in fatty tissue.

Scientists do not fully understand the roles of different proteins which regulate people’s metabolism – how the body burns fat.

And strong, suitable drugs for controlling fat production have been difficult to produce in the past.

But PO53 stops the activity of fat-producing enzyme CerS1 in its tracks, reducing fat across the whole body without effecting insulin resistance in mice fed on a high-fat diet.

‘Our work so far has been a very important step’ 

Professor Turner and colleagues his believe it was due to the drug boosting the burning of fatty acids in the muscles of the animals.

Co-author Professor Anthony Don, of the University of Sydney, added: ‘From here, I would like to develop drugs which target both the CerS1 and [other] enzymes together, and see whether it produces a much stronger anti-obesity and insulin sensitising response.

‘Although these drugs need more work before they are suitable for use in the clinic, our work so far has been a very important step in that direction.’

WHAT IS THE GLOBAL OBESITY CRISIS? 

Almost a quarter of the world’s population will be obese in less than 30 years, according to research published in May.

If obesity trends continue, 22 per cent of people around the world will be severely overweight by 2045, up from 14 per cent last year, a study found.

One in eight people, rather than today’s one in 11, are also expected to develop type 2 diabetes, the research adds.

Lead author Dr Alan Moses, from the Denmark-based pharmaceutical company Novo Nordisk, said: ‘These numbers underline the staggering challenge the world will face in the future in terms of numbers of people who are obese, or have type 2 diabetes, or both.

‘As well as the medical challenges these people will face, the costs to countries’ health systems will be enormous.’

People with type 2 diabetes have an average life expectancy of just 55 due to them being at a much higher risk of heart attacks, stroke and kidney disease. 

Tam Fry, a health campaigner from the National Obesity Forum said the findings were ‘desperately sad’. 

 

Read more at DailyMail.co.uk


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