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Smoking AGES you: Scientists discover under 40s ‘are biologically TWICE their age’

Smokers in their 20s are biologically TWO DECADES older than they should be, ‘fascinating’ study reveals

  • Over 70% of smokers under 30 were predicted to be as old as 50, study showed
  • Blood tests and AI were used to make the predictions of their biological age
  • The methods are more accurate than self-reporting by patients, experts said 

Smokers in their twenties are biologically two decades older than they should be, according to the first study of its kind.

Researchers now warn the ‘fascinating evidence’ proves the notoriously bad habit accelerates the ageing process. 

The human body has two different ages – chronological and biological. The latter refers to how old a person seems.

Scientists analysed blood samples from tens of thousands of volunteers to assess how smoking can affect biological ageing.

Smokers are up to twice their biological age, and that of non-smokers, scientists have revealed

They predicted the majority of smokers under the age of 30 to actually be aged between 31 and 40 – or 41 to 50. 

On the other hand, the ages of 62 per cent of the non-smokers were calculated accurately, the researchers discovered.

The same trend was found for 31 to 40 year olds, in which the ages of almost half of the smokers were predicted to be 41 to 50.

Older smokers did not show such effects – possibly because those most affected had already died, the researchers said.

The research was carried out by Baltimore-based artificial intelligence solutions company Insilico Medicine.

The results were carried out based on the blood profiles of 149,000 adults, of which 33 per cent (49,000) reported being smokers.  

Smokers and non-smokers were matched for age, sex and geography of residence.  

The researchers combined an age-prediction model using a technique called deep learning and various biochemical markers among the participants.

These included levels of blood sugar, fasting glucose, iron stores and urea, a waste product excreted in urine.   

The findings, published in Scientific Reports, showed that females smokers were worse off than males, in terms of their biological age.  

Study author Dr Polina Mamoshina said: ‘Compared with non-smokers, smokers showed an accelerated rate of ageing through to age 55 years regardless of sex.’ 

HANG AROUND VAPERS TO QUIT SMOKING, EXPERTS SAY 

Smokers who regularly spend time with vapers are 20 per cent more likely to try and quit, research in November 2018 suggested.

Scientists at University College London claimed that being around e-cigarette users encourages smokers to try the gadgets themselves.

The researchers said the findings should ease concerns about vaping, which has been linked to heart and lung damage.

Roughly a quarter of smokers (25.8 per cent) who participated in the study said they regularly spent time with vapers.

Of these, around a third (32.3 per cent) had made an attempt to quit smoking in the previous year.

By comparison, around a quarter (26.8 per cent) of smokers who did not regularly spend time with vapers attempted to quit in the previous year.

‘The contribution of tobacco smoking as an external factor of ageing may eventually be masked by the… deleterious nature of the ageing process.

‘Alternatively, the people most affected by smoking may have died at an earlier age and thus were be excluded from the old-age smoking group.’   

Previous research has shown biological age is more useful than using a date of birth for predicting when a person will die.

Her team say the analysis of blood tests could soon replace traditional self-reporting methods used to evaluate the effects on ageing of other lifestyle choices such as diet, exercise and alcohol consumption.

Insilico Medicine uses artificial intelligence, or computer learning, to research ageing and drug development to ‘extend healthy longevity’.

Dr Mamoshina said: ‘We applied artificial intelligence to prove that smoking significantly increases your biological age.

‘I am pleased to be part of the research study, which provides fascinating scientific evidence that smoking is likely to accelerate ageing.’ 

In the UK there are an estimated 9.4 million current smokers, roughly 19 per cent of the population, and 38 million in the US.

It is the biggest cause of death and illness in Britain, claiming more than 120,000 lives each year through associated diseases.

This means it accounts for over a fifth of deaths, similar to the US where it is responsible for about 480,000 deaths annually.

Read more at DailyMail.co.uk


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