Theresa May looks certain to face a vote of no confidence after her Brexit deal was rejected out of hand by Eurosceptics.
If she loses the Tory Party will launch a leadership contest to replace her – a process that will likely take weeks with just months until Brexit Day.
These are some of the leading contenders to replace her:
Dominic Raab
How did they vote on Brexit?
Leave, with a second tier role campaigning for Vote Leave.
What is their view now?
Mr Raab was installed as Brexit Secretary to deliver the Chequers plan but sensationally resigned today saying the deal is not good enough.
What are their chances?
Being the first to resign from the Cabinet has put a rocket booster under Mr Raab’s chances, fuelling his popularity among the hardline Brexiteers. May struggle to overcome bigger beasts and better known figures.
Odds: About 11-2
Newly installed as Brexit Secretary, Dominic Raab (pictured in Downing Street on Tuesday) is trying to negotiate Theresa May’s Brexit deal
Boris Johnson
How did they vote on Brexit?
Led the Vote Leave campaign alongside Michael Gove.
What is their view now?
Hard line Brexiteer demanding a clean break from Brussels. The former foreign secretary is violently opposed to Theresa May’s Chequers plan and a leading voice demanding a Canada-style trade deal.
What are their chances?
Rated as second favourite by the bookies, Mr Johnson’s biggest challenge will be navigating the Tory leadership rules. He may be confident of winning a run-off among Tory members but must first be selected as one of the top two candidates by Conservative MPs.
Odds: 5/1
Rated as second favourite by the bookies, Boris Johnson’s (pictured at Tory conference last month) biggest challenge will be navigating the Tory leadership rules
Sajid Javid
How did they vote on Brexit?
Remain but kept a low profile in the referendum.
What is their view now?
Pro delivering Brexit and sceptical of the soft Brexit options.
What are their chances?
Probably the leading candidate from inside the Cabinet after his dramatic promotion to Home Secretary. Mr Javid has set himself apart from Mrs May on a series of policies, notably immigration.
Favourite with several of the bookies at around 5/1.
Sajid Javid (pictured in Downing Street) is probably the leading candidate from inside the Cabinet after his dramatic promotion to Home Secretary
Jeremy Hunt
How did they vote on Brexit?
Remain.
What is their view now?
The Foreign Secretary claims the EU Commission’s ‘arrogance’ has made him a Brexiteer.
What are their chances?
Another top contender inside Cabinet, Mr Hunt’s stock rose during his record-breaking stint at the Department of Health and won a major promotion to the Foreign Office after Mr Johnson’s resignation. Widely seen as a safe pair of hands which could be an advantage if the contest comes suddenly.
Rated around 8/1 by the bookies.
Jeremy Hunt’s stock rose during his record-breaking stint at the Department of Health and won a major promotion to the Foreign Office after Mr Johnson’s resignation
David Davis
How did they vote on Brexit?
Leave.
What is their view now?
Leave and a supporter of scrapping Mrs May’s plan and pursuing a Canada-style trade deal with the EU.
What are their chances?
The favoured choice of many hard Brexiteers. Seen as a safer pair of hands than Mr Johnson and across the detail of the current negotiation after two years as Brexit Secretary. He could be promoted a caretaker to see through Brexit before standing down.
Unlikely to be the choice of Remain supporters inside the Tory Party – and has been rejected by the Tory membership before, in the 2005 race against David Cameron.
Rated around 11/1 by the bookies.
David Davis (pictured last month at a Brexiteer policy launch) is seen as a safer pair of hands than Mr Johnson and across the detail of the current negotiation after two years as Brexit Secretary
Amber Rudd
How did they vote on Brexit?
Remain. Represented Britain Stronger in Europe in the TV debates.
What is their view now?
Strongly remain and supportive of a second referendum – particularly given a choice between that and no deal.
What are their chances?
Popular among Conservative MPs as the voice of Cameron-style Toryism, Ms Rudd is still seen as a contender despite resigning amid the Windrush scandal. Badly hampered by having a tiny majority in her Hastings constituency and would not be able to unite the Tory party in a sudden contest over the Brexit negotiation.
Out to 50/1 among many bookies.
Popular among Conservative MPs as the voice of Cameron-style Toryism, Amber Rudd (pictured at Tory conference last month) is still seen as a contender despite resigning amid the Windrush scandal
Penny Mordaunt
How did they vote on Brexit?
Leave
What is their view now?
Leave and subject of persistent rumour she could be the next to quit Cabinet over Mrs May’s Brexit deal.
What are their chances?
Possible dark horse in the contest, Ms Mordaunt is not well known to the public but is seen as a contender in Westminster. She has been encouraged to join the Cabinet revolt over the Brexit deal and could resign within hours.
Bookies rate her around 16/1.
Possible dark horse in the contest, Penny Mordaunt (pictured in Downing Street) is not well known to the public but is seen as a contender in Westminster