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People’s eyes could predict their risk of dementia

People’s eyes could predict their risk of dementia, new research suggests. 

Sixty-year-olds with moderate-to-severe retinal damage are more likely to experience thinking and memory problems by the time they reach 80, a study found today. 

Among people with moderate-to-severe retinal damage, known as retinopathy, their average memory and cognitive test scores declined by 1.22 points over 20 years, compared to just 0.91 for those with healthy eyes, the research adds.

Study author Dr Jennifer Deal from Johns Hopkins University, said: ‘If our study results can be confirmed, differences in retinal integrity could provide reasonable estimates of how much small blood vessel damage in the brain is contributing to cognitive decline.’

Diabetic retinopathy, which occurs as a complication of the high-blood sugar condition, affects around 5.4 percent of adults over 40 in the US. 

One in eight people over 65 in the US have Alzheimer’s disease, which is the most common form of dementia.

People’s eyes could predict their risk of dementia, new research suggests (stock)


A breakthrough Alzheimer’s drug edges scientists one step closer to a cure, new research suggested in November 2017.

Taken twice a day, a tablet, known as LMTX, significantly improves dementia sufferers’ brain injuries to the extent their MRI scans resemble those of healthy people after just nine months, a study found.

Lead author Professor Gordon Wilcock from the University of Oxford told MailOnline: ‘I haven’t seen such brain injury recovery before after a drug treatment.’

LMTX, which is under investigation, also significantly improves patients’ abilities to carry out everyday tasks such as bathing and dressing themselves, while also boosting their capabilities to correctly name objects and remember the date, the research adds.

The drug contains a chemical that dissolves protein ‘tangles’ in the brain that clump together to form plaques in the region associated with memory, according to its manufacturer TauRx Pharmaceuticals.

Dissolving these tangles and preventing the formation of new plaques may slow or even halt memory loss in dementia sufferers, the pharma company adds. 

The researchers, from the universities of Oxford and Aberdeen, analysed 800 Alzheimer’s patients across 12 countries.

The study’s participants received either 100mg or 4mg LMTX tablets twice a day for 18 months.

They were tested on their ability to name objects, follow commands such as ‘make a fist’, recall items from a list of 10 and identify their name, the time and date.

Their ability to eat without help, use a telephone, wash and dress themselves, and control their bowel and bladder was also assessed.

MRI scans monitored the participants’ brain injury. 

Study did not specifically evaluate dementia onset  

Speaking of the findings, Dr Sara Imarisio, head of research at Alzheimer’s Research UK, said: ‘Exploring how our eyes can shed light on changes underway in the brain is an area that is attracting more and more research attention. 

‘As the brain is so well protected we can only visualise it indirectly, often through expensive brain scans. 

‘The retina offers a potentially valuable window into the brain, and it can be studied with cheaper, non-invasive eye scans.

‘While this research highlights a specific change in the retina that may be linked to a decline in memory and thinking skills, it didn’t investigate whether these changes were related to a higher risk of dementia. 

She said: ‘There is a desperate need for better ways to diagnose the diseases that cause dementia so that people can get access to support, treatments and opportunities to take part in research. 

‘Further studies will be needed to evaluate whether techniques like this could one day support doctors making a diagnosis in the clinic and continued investment in research is vital to ensure this progress.’ 

The study’s method has also been criticised for only taking photos of one of each of the participants’ eyes. 

How the research was carried out 

The researchers analysed 12,317 people who completed memory and thinking skills tests.

These were repeated around six years and 20 years later.

A specialist retinal camera took photos of the back of the participants’ eyes approximately three years after the start of the study, when the participants had an average age of 60.

Dr Deal said: ‘Problems with the small blood vessels in the brain are likely as important a factor in cognitive decline as problems with larger arteries, but we don’t have the ability to take pictures of these small vessels with brain imaging.

‘Because the blood vessels in the eye and the brain are so similar anatomically, we hypothesised that looking at the blood vessels in the eye would help us understand what was happening in the brain.’ 

Of the study’s participants, 11,692 had no signs of retinopathy or blood-vessel related retinal damage, 365 people had mild retinopathy and 256 people had moderate-to-severe damage. 

The findings were published in the journal Neurology.

Past research found exercise like running may halt dementia by preventing brain shrinkage

Past research found exercise like running may halt dementia by preventing brain shrinkage

Exercise may halt dementia by preventing brain shrinkage  

This comes after research released in November last year suggested aerobic exercise, such as walking or running, may halt dementia by preventing the brain from shrinking.

Being active several times a week maintains the size of the region of the brain associated with memory, a study found.

Known as the hippocampus, this region is often one of the first to deteriorate in Alzheimer’s patients.

Lead author Joseph Firth from the Western Sydney University, said: ‘When you exercise you produce a chemical called brain-derived neurotrophic factor (BDNF), which may help to prevent age-related decline by reducing the deterioration of the brain.

‘In other words, exercise can be seen as a maintenance programme for the brain.’